Propranolol (CAS 525-66-6), designated chemically as (RS)-1-(1-methylethylamino)-3-(1-naphthyloxy) propan-2-ol, is cheap and commercially available chemical. Propranolol is a β1-selective (cardioselective) β-adrenergic receptor blocking agent which was discovered in 1988 by the scientists Scottish and James W. Black. They achieved Nobel prize for their discovery of Propranolol molecules.1 One of the most widely prescribed as sympatholytic non selective β-blockers in the long term treatment of hypertension and cardiovascular diseases is usually taken orally, although an intravenous form is available for acute administration. Propranolol is rapidly absorbed from gastrointestinal tract, but the oral bioavailability is low nearer to 30% due to significant first pass metabolism. Propranolol is rapidly and completely absorbed, with peak plasma levels achieved approximately 1–3 hours after ingestion. Effective plasma concentrations are between 10–100 ng/mL. Toxic levels are associated with plasma concentrations above 2000 ng/ml. 2 the present work was attributed to the formation of injection having hydrogels base control drug delivery system of Propranolol. The formulations contain microparticles were prepared by using biodegradable polymer like Polycaprolactone.
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